Safer vehicles by redesign

34 4 Are Electric Vehicles Safer than Combustion Engine Vehicles ?

Crash-related mortality and model year: are newer vehicles safer?

OBJECTIVE The objective of this study was to determine whether occupants of newer vehicles experience a lower risk of crash-related mortality. METHODS The occurrence of death was studied in relation to vehicle model year (MY) among front seat vehicular occupants, age ≥ 16 captured in the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) between 2000 and 2008. The asso...

Enzyme Redesign by SVM

In [1], a new support vector machine (SVM)-based approach was proposed to predict the substrate (adenylation domain, or A domain in short) specificity of subtypes of a given protein sequence family (nonribosomal peptide synthetases, or NRPS in short). Based on the physico-chemical properties of the amino acids, the residues of NRPS were first encoded into vectors in high dimensional feature spa...

Safer Classification by Synthesis

The discriminative approach to classification using deep neural networks has become the de-facto standard in various fields. Complementing recent reservations about safety against adversarial examples, we show that conventional discriminative methods can easily be fooled to provide incorrect labels with very high confidence to out of distribution examples. We posit that a generative approach is...

Protein redesign by learning from data.

Protein redesign methods aim to improve a desired property by carefully selecting mutations in relevant regions guided by protein structure. However, often protein structural requirements underlying biological characteristics are not well understood. Here, we introduce a methodology that learns relevant mutations from a set of proteins that have the desired property and demonstrate it by succes...